“A new study, published in Nature this January, Schizophrenia risk from complex variation of complement component 4links , complement component 4 (C4) genes to schizophrenia. C4 genes are important in the major histocompatibility complex (MHC). C4 was found to mediate synapse elimination (called pruning) in development after birth, in mice. These findings might therefore help to explain the reduced number of synapses in brains of humans with schizophrenia.
(Sekar et al., 2016)