Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization.

Highlights

• ERK binds a non-canonical docking motif in the Arc C-terminal domain.
• In vitro kinase assays identify five ERK phosphorylation sites on Arc.
• Stimulus-evoked phosphorylation occurs on Ser206 in the central hinge region of Arc.
• Phosphorylation regulates Arc subcellular localization in hippocampal neurons.
• Endogenous Arc is Ser206 phosphorylated during LTP in live rats.