Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization.



  • ERK binds a non-canonical docking motif in the Arc C-terminal domain.
  • In vitro kinase assays identify five ERK phosphorylation sites on Arc.
  • Stimulus-evoked phosphorylation occurs on Ser206 in the central hinge region of Arc.
  • Phosphorylation regulates Arc subcellular localization in hippocampal neurons.
  • Endogenous Arc is Ser206 phosphorylated during LTP in live rats.

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