ADHD is a common (~3.5% in adulthood and ~5% in childhood) childhood onset neuropsychiatric condition, leading to high disability because of the frequent psychiatric co-morbidities such as substance abuse, major depression and learning disabilities. Thus, the treatment of ADHD is of high relevance to our society, especially as untreated ADHD has been linked to unemployment, criminality and suicidal attempts. To date, the most effective pharmacological therapy includes methylphenidate and atomoxetine, chemical compounds that affect dopaminergic and noradrenergic neurotransmission. But it is important to consider and study the alternative drugs as they may provide help in dealing with resistant ADHD symptoms and/or co-morbid conditions. The following article provides comprehensive overview of such alternatives: Alternative pharmacological strategies for adult ADHD treatment: a systematic review. In short, amphetamines, antidepressants and metadoxine may be considered suitable pharmacological treatments for symptoms of ADHD and its co-morbid conditions.